A study of nearly 55,000 participants found that individuals with psychological distress markers before a COVID-19 diagnosis were nearly 1.5 times more likely to show symptoms of post-COVID-19 conditions (commonly referred to as long COVID). Depression, anxiety, worry about contracting COVID-19, loneliness and stress were associated with complications post-COVID-19 infection and impairment in daily living, even after adjusting for health-related factors. Individuals with two or more types of psychological distress were the most likely to present post-COVID-19 conditions. Future research should explore whether interventions to reduce psychological distress can help prevent or mitigate physical health conditions, such as long COVID. To learn more, see the study in JAMA Psychiatry.