Combination Ketamine-Behavioral Therapy Shows Heightened, Prolonged Antidepressant Effects

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Ketamine has been found to be highly effective for treatment-resistant depression, but its fast-acting effects typically do not last more than one to two weeks. A randomized clinical trial of 154 adults with moderate to severe depression measured how a behavioral therapy known as “active automated self-association training” (ASAT) influenced the antidepressant effects of intravenous ketamine infusion. After 30 days, adults who received a ketamine infusion with ASAT reported the lowest depression scores compared to either adults who received ketamine with placebo ASAT or sham ketamine with ASAT. The findings suggest that the antidepressant effects of ketamine may be strengthened and lengthened in combination with behavioral therapy. To learn more, see the study in the American Journal of Psychiatry.
 

About Mental Illness

A mental illness is a medical condition that disrupts a person’s thinking, feeling, mood, ability to relate to others and daily functioning.

What is Recovery

Recovery from serious mental illness is not only possible, but for many people living with mental illness today, probable. The notion of recovery involves a variety of perspectives.

We’re Here to Listen

In Crisis?

You can chat one-to-one online at:
www.Foundation2CrisisChat.org
Online & texting chats are available from 9am-3pm M-F. All contacts are confidential.

Call the NAMI Helpline at

1-800-950-NAMI (6264)

Or in a crisis, text “NAMI” to 741741

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