For individuals with depression, multiple antidepressants may be prescribed if the person is not experiencing enough benefit from a single medication. In a recent systematic review and meta-analysis, researchers explored findings from nearly 40 previous studies to assess the tolerability and efficacy of combination therapy compared to monotherapy. Combination treatment was found to offer improved outcomes not only for individuals who did not respond to monotherapy, but also as a first-line treatment in some patients. The researchers also found that certain medication combinations were more effective than others, suggesting that combining any two antidepressants may not provide similar benefits. To learn more, see the study in JAMA.