Engagement and retention of participants in clinical mental illness research studies can be low. To better understand the perspectives of direct stakeholders, researchers surveyed individuals diagnosed with a schizophrenia spectrum condition (SSC) and caregivers of a family member with a SSC regarding their knowledge, comfort, concerns and preferences related to mental illness clinical research. 67 individuals with a diagnosis and 131 caregivers were include in the final analysis. Overall, individuals with a diagnosis and caregivers were interested in engaging with clinical research. While respondents expressed discomfort with certain research procedures, the authors demonstrate that educational materials tailored to the concerns voiced by these populations may increase meaningful engagement. To learn more, see the study in Psychiatry Research.